 Bruce
D. Gaynor, MD
Assistant Clinical Professor of Ophthalmology
Other Activities
Private practice, Santa Rosa, CA
Contact Information
4720 Hoen Ave.
Santa Rosa, CA 95405
Phone: 707-527-8222
Related Link
www.gaynornd.com
Education
# MD: Chicago Medical School
# Residencies: Internal Medicine, Albert Einstein College
of Medicine, New York, NY; Ophthalmology, Lenox Hill Hospital/New
York University, New York, NY
# Fellowships: Microbiology & Immunology, Albert Einstein
College of Medicine, New York, NY; Cornea, Uveitis, External
Disease, F.I. Proctor Foundation, University of California
at San Francisco
Research Interests
Trachoma elimination—The World Health Organization (WHO), in association with
non-governmental organizations, academic institutions and
national health services has implemented a program to eliminate
blinding trachoma by the year 2020. There is evidence that
a single course of mass antibiotic administration can have
a dramatic effect on the prevalence of active trachoma in
a community. In support of the WHO program, we are conducting
clinical trials in Ethiopia to develop efficient and cost-effective
treatment strategies for the elimination of trachoma.
Modeling antibiotic resistance in bacteria—Mass antibiotic administrations for the elimination of chlamydia
infection of the eye offer an unprecedented opportunity to
both model the emergence of antimicrobial resistance and to
test the model's predictions empirically. We are conducting
clinical trials in Nepal and Ethiopia with azithromycin for
trachoma We are also determining the prevalence of macrolide-resistant
pneumococcus before and after multiple mass distributions.
We will use modeling techniques to predict how much resistance
will emerge after multiple rounds of mass antibiotic administrations,
and then test these predictions by collecting data from the
field.
Representative Publications
Gaynor BD, Miao Y, Cevallos V, Jha H, Chaudary J, Bhatta
R, Osaki-Holm S, Yi E, Schachter J, Whitcher J, Lietman T.
Eliminating trachoma in areas with limited diasese. Emerging
Infectious Diseases 2003. 9:596-598.
Gaynor BD, Holbrook K, Whitcher J, Osaki-Holm S. Stephens
RS, Jha HC, Chaudhary JSP, Bhatta RC, Fry A. Lietman T. Community
treatment with azithromycin for trachoma is not associated
with antibiotic resistance in Streptococcus pneumoniae
at one year. British Journal of Ophthalmology 2003. 87:147-8.
Melese M, Wondu A. Gaynor BD, Yi E, Whitcher J, Lietman
T. What more is there to learn about trachoma? British
Journal of Ophthalmology 2003. 87:521-2.
Miller K, Pakpour N, Yi E, Melese M, Alemayehu W, Bird M,
Schmidt G, Cevallos V, Olinger L, Chidambaram J, Gaynor BD,
Whitcher J, Lietman T. Pesky trachoma suspect finally caught.
British Journal of Ophthalmology In Press, 2003.
Jha H, Chaudary JSP, Bhatta R, Miao Y, Osaki-Holm S, Gaynor
BD, Zegans M, Bird M, Yi E, Holbrook K, Whitcher J, Lietman
T. Disappearance of trachoma from western Nepal. Clinical
Infectious Disease 2002. 35:765-8.
Gaynor BD, Yi Elizabeth, Lietman, T. Rationale for mass
antibiotic distribution for trachoma elimination. International
Ophthalmology Clinics 2002. 42:85-92.
Gaynor BD, Wade NK, Cunningham ET. Herpes simplex virus-1
associated acute retinal necrosis following encephalitis.
Retina 2001. 21:688-690.
Gaynor BD, Stamper R, Cunningham, ET. Presumed activation
of Herpetic keratouveitis following argon laser peripheral
iridotomy. American Journal of Ophthalmology 2000.
130:665-7.
Gaynor BD, Margolis T, Cunningham ET. Advances in herpes
keratouveitis diagnosis and management. International Ophthalmology
Clinics 2000. 40:85-109.
Gaynor BD, Putterman C, Valadon P, Spatz L, Scharff M, Diamond
B. Peptide inhibition of glomerular deposition of an anti-DNA
antibody. Proc Nat Acad Sci1997. 94:1955-60. Complete
Medline Listing |
