John A. Gonzales, MD

John A. Gonzales, MD
Associate Professor, Francis I. Proctor Foundation

Uveitis and Sjögren's Disease — Ocular Inflammation, Dry Eye, and Molecular Diagnostics

About

Dr. Gonzales's interests involve the diagnosis and management of infectious and non-infectious inflammatory conditions of the eyes, including uveitis and Sjögren's disease-associated dry eye. His research combines epidemiologic studies and randomized clinical trials in ocular inflammatory disease. He is funded by the National Eye Institute to study keratoconjunctivitis sicca in Sjögren's syndrome — including dry eye diagnostic criteria, quality-of-life measures, depression, and mortality outcomes within the Sjögren's International Collaborative Clinical Alliance cohort. His current work also includes clinical trials for CMV anterior uveitis, molecular studies of vitreoretinal lymphoma, and high-throughput sequencing studies to identify novel biomarkers in ocular sarcoidosis.

Education & Training

HHMI Research Scholar, Laboratory of Immunopathology — National Eye Institute, NIH
MD — Keck School of Medicine, University of Southern California
Internship, Internal Medicine — University of Southern California
Residency, Ophthalmology — University of Texas Medical Branch
Fellowship, Uveitis — F.I. Proctor Foundation, UCSF

Research Projects

Ongoing

Sjögren's Team for Accelerating Medicines Partnership (STAMP)

STAMP applies cutting-edge technologies to investigate the tissue and systems biology of Sjögren's disease, identify therapeutic targets and biomarkers, and study disease progression from non-Sjögren's to early and advanced Sjögren's disease. Dr. Gonzales serves as the study ophthalmologist and performs ocular examinations for STAMP at the UCSF site.
Role: Study Ophthalmologist (UCSF site)
Focus: Sjögren's disease biology & biomarkers
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Sjögren's International Collaborative Clinical Alliance — Next Generation Studies (SICCA-NextGen)

SICCA-NextGen leverages NIDCR-funded resources and an expert multidisciplinary team to better understand Sjögren's disease pathogenesis, identify therapeutic pathways, and discover new biomarkers.
Funder: NIH / NIDCR
Focus: Cohort & biorepository research
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Systemic and Topical Antiviral Control of CMV Anterior Uveitis: Treatment Outcomes (STACCATO)

CMV anterior uveitis is an important infectious cause of anterior uveitis and may lead to vision loss through corneal damage and glaucoma. STACCATO evaluates antiviral treatment strategies for active CMV anterior uveitis through multicenter, international, randomized, placebo-controlled trials. The pilot phase has completed, and the broader study continues.
Role: Principal Investigator
Sites: USA, Thailand, Taiwan

Key Collaborators

Thomas Lietman, MD Thuy Doan, MD, PhD Nisha Acharya, MD, MS Caroline Shiboski, DDS, PhD Lindsey Criswell, MD, MPH Vatinee Bunya, MD Jennifer Rose-Nussbaumer, MD Gerami Seitzman, MD Jeremy Keenan, MD Thanapong Somkijrungroj, MD (Thailand)

Learn More

UCSF Profile & Full Publication List

Research Areas: Uveitis, Sjögren's Disease, Ocular Inflammation, Molecular Diagnostics

Learn more about UCSF Ophthalmology faculty research