Genomic Approaches to Ocular Infection, Inflammation, and the Microbiome
About
Dr. Doan directs the Ralph and Sophie Heintz Laboratory at the F.I. Proctor Foundation. Her research uses genomic technologies to identify and characterize infectious and autoimmune causes of uveitis. Working with Dr. Lietman, she studies how the human microbiomes — ocular, gut, and upper respiratory — respond to clinically relevant perturbations in randomized controlled trials.
For more on the lab's work, visit the Doan Lab research pages.
Education & Training
PhD, Medical Scientist Training Program — University of Washington
MD — Stanford University
Summer Course, Neurobiology — Marine Biological Laboratory, Woods Hole
Intern, Preliminary Medicine — Santa Clara Valley Medical Center
Residency, Ophthalmology — University of Washington
Fellowship, Uveitis — University of Washington
Key Collaborators
Funding Support
Learn More
UCSF Profile & Full Publication List
Research Areas: Ocular Infection, Uveitis, Metagenomic Sequencing, Microbiome, Antimicrobial Resistance
Research Projects
Conjunctivitis Epidemics Worldwide (SCORPIO)
An international, multi-site study using advances in genomic technologies to understand conjunctivitis epidemics globally — identifying the pathogens involved, characterizing how pathogen genomes evolve across time and space, and defining the immune responses to these infections.
Doan Lab →
Pathogens, Resistomes and Inflammatory Markers in the Cornea (capriCORN)
Comprehensive analysis of pathogens, resistomes, and inflammatory markers in the cornea, bringing sequencing-based methods to bear on corneal infection.
Doan Lab →
Metagenomic Sequencing for Intraocular Infection (OPTICS)
A multi-site randomized controlled trial comparing metagenomic deep sequencing against standard-of-care testing, to determine whether sequencing improves outcomes for patients with intraocular infections.
American Journal of Ophthalmology →
Antibiotic Resistance on the Ocular Surface (ARIES)
A randomized controlled trial evaluating how topical antibiotics affect the ocular surface resistome and microbiome, alongside other systemic sites including the nasopharynx, mouth, and gut.
Registry: NCT04750655
Protocol & statistical analysis plan →
Pathogen Detection for Ocular Infections
Optimizing deep sequencing approaches so that pathogen detection becomes a practical diagnostic tool for clinicians treating ocular infections, and for the patients who depend on a faster answer.
PubMed →
Mass Drug Administration and Child Mortality (MORDOR)
Large randomized controlled trials in Niger and Burkina Faso evaluating whether mass drug distribution reduces childhood mortality, with the lab characterizing the microbiome and resistome consequences.
Doan Lab →
Trachoma Surveillance & Molecular Assays
The Proctor Foundation was founded in 1947 with the aim of trachoma eradication. The laboratory works closely with Proctor faculty to design, optimize, and implement molecular assays that improve surveillance and treatment paradigms.
Doan Lab →
Azithromycin for COVID-19 (ACTION)
A research study testing whether azithromycin could help treat COVID-19 disease in outpatients.
Registry: NCT04332107
UCSF Ophthalmology →
More at the Doan Lab research pages.